Application of antigen cross-presentation research into patient care.

Thijs W H Flinsenberg,Marianne Boes

doi:10.3389/fimmu.2014.00287

Abstract

EDITORIAL article Front. Immunol., 17 June 2014Sec. Antigen Presenting Cell Biology Volume 5 - 2014 | https://doi.org/10.3389/fimmu.2014.00287

Highlights

Dendritic cells are professional antigen presenting cells (APCs) that are well endowed to elicit adaptive immune responses, via the presentation and cross-presentation of antigen-derived peptide/MHC complexes to T-lymphocytes. These processes decide how the host interacts with its environment, and can be a target for pathogen interruption. van Montfoort et al (1) provide an overview of cross-presentation features and describe how the study of various viral pathogens can elucidate anti-viral immune strategies. They further describe how DC maturation is crucial in immunity against viruses and how viruses may dampen this response to their own advantage
While monocyte-derived DCs (MoDCs) can be found in human tissue under inflamed conditions, other DC subsets are more prevalent overall and may be endowed at stimulation of particular T-cell subsets, to be explored in immunotherapy
Tullett et al (7) highlight recent findings explaining why these cells are effective at CD8+ T-cell priming and discuss in vivo antigen targeting toward these DCs

Summary

Introduction

Dendritic cells are professional antigen presenting cells (APCs) that are well endowed to elicit adaptive immune responses, via the presentation and cross-presentation of antigen-derived peptide/MHC complexes to T-lymphocytes. Van Montfoort et al (1) provide an overview of cross-presentation features and describe how the study of various viral pathogens can elucidate anti-viral immune strategies. Understanding these presentation pathways is pivotal to develop effective DC-based immunotherapy.

Results

Conclusion