Abstract
Diabetes mellitus (DM) is a disease associated with lifestyle, especially food consumption. One way to treat the pathogenesis of diabetes is by providing antioxidants which are proton compounds to reduce the negative effects of ROS, so that antioxidants can prevent interactions between radicals. African leaves contain flavonoid compounds, glycosides, saponins, tannins, and triterpenoids/steroids that function as primary antioxidants and scavenger to superoxide anions. The purpose of this study was to apply the African leaves extract ( Vernonia amygdalina Delile) as a drug of diabetes mellitus and identify the active compound. The results showed that African leaves had an effect on blood glucose levels of diabetic rats and the concentration of African leaves extract which had an effect on the decrease of glucose level was 60% extract and began to show a decrease at the time of process 30 minutes to 150 minutes with glucose level 75 mg / dl . The content of African leaves extract ( Vernonia amygdalina Delile) phytochemical results showed the presence of flavonoid, terpenoid, phenolic, alkoloid, and saponin compounds that function as antioxidants.
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