Abstract
AbstractA novel synthesized tetraamino cobalt(II) phthalocyanine monomer was used for the fabrication of a sensor by electrochemical polymerization. A disposable electrochemical sensor based on the use of a screen printed carbon electrode covered with an electropolymerized film of tetraamino cobalt(II) phthalocyanine for the determination of L‐dopa in pharmaceutical tablets and biological samples was described. Cyclic voltammetry and electrochemical impedance spectroscopy were performed for the characterization of the bare and modified electrode. For the electrochemical detection of L‐dopa differential pulse voltammetry was used. The proposed method exhibits a good response towards electrooxidation of L‐dopa in the linear concentration range: from 0.1 to 1000.0 μmol L−1 in BRB pH=2.0, with a detection limit of 0.03 μmol L−1 and from 1 to 1000 μmol L−1 in PBS pH=7.4, with a detection limit of 0.33 μmol L−1. Due to the fact that the developed sensor was applied in two different types of real samples, two buffer media were used, BRB pH=2.0 for pharmaceutical and urine samples and PBS pH=7.4 for whole blood samples. The proposed pCoTAPc/SPCE was successfully applied for the determination of L‐dopa in pharmaceutical tablets, urine and in whole blood samples with satisfactory results.
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