Abstract
Green tea leaves contain lots of polyphenols and antioxidants that can reduce cell damage and prevent premature aging. Green tea extract is made in gel preparation to make it easier to use and increase convenience. HPMC base with propylene glycol additives can increase drug release and increase drug penetration into the skin. This study aims to optimize the levels of HPMC and propylene glycol in green tea extract gel formulations using the D-optimal method and calculate the total release of polyphenols using the Franz diffusion cell method. The extract is produced by infundation. The gel preparation was formulated by varying HPMC and propylene glycol levels in the manufacturing process. Each gel was evaluated for its physical properties, namely viscosity test, pH test, and dispersion test. The physical properties data obtained were then analyzed using Design-Expert software in the mixture design program to obtain the optimum formula. The optimum formula obtained was HPMC with a concentration of 6% and propylene glycol with a concentration of 17% resulting in the best correlation between viscosity, dispersion, and pH, with a desirability value of 0.921. In the green tea gel preparation, the resulting concentration was 8.00 GAE/g sample, and the gel content released at 360 min. was 3.30 GAE/g sample.
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