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https://doi.org/10.3760/cma.j.issn.1673-4173.2007.05.019
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Cite Publication Date: Sep 15, 2007 |
硬皮病是一种自身免疫性结缔组织疾病,严重影响患者的生活质量.该病的病因和发病机制尚未完全明了,临床上也无理想的治疗方法,在进行基础研究时患者依从性相对较差.因此建立硬皮病的动物模型,对于深入研究本病的发病机制和评价治疗方法有重要意义.综述近十年来利用不同品系的鼠科动物建立的各种硬皮病模型,以及利用这些模型从不同的角度阐明硬皮病可能的发病机制,并在新药筛选和新疗法评价方面取得的一些进展。
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