Applicated value of rosuvastatin in the treatment of coronary heart disease patients with diabetes

Abstract

Objective To compare main adverse cardiac events of patients with coronary heart disease and diametes,but normal lipids after statin on lowering lipids , and to bring out necessity of early lowering lipids . Methods A total of 324 patients with coronary heart disease and diametes were enrolled ,LDL-C was measured in-hospital for all patients and LDL-C〈3.36mmol/L suitable for the experiment .They were divided into statin group （n=176,rosuvastatin 10 mg/d）and control group（n=148）randomly,all patients received second prevention for cor-onary heart disease including anti-platelet,anti-myocardial ischemia,smoke quitting,adjust diets and exercise,the CAG or PTCA（and stent implanting）,CABG.the end events were main adverse cardiac events （cardiac events,recur-rent angina and target vessel reconstruction ）.The mean follow-up time was（13 ±6）months.Results The fasting plasma glucose,LDL-C,hs-CRP in statin group were all significantly lower than those of control group [FPG：（5.3 ± 0.9）vs.（6.7 ±1.2）mmol/L,P=0.042;LDL-C：（1.7 ±0.6）mmol/Lvs.（3.9 ±1.6）mmol/L,P〈0.01;hs-CRP：（1.4 ±0.5）mmol/L vs.（3.8 ±1.2）mg/L,P 〈0.01],MACE were less（15.6% vs.37.1%,P =0.032）. Conclusion Early statin on patient with coronary heart disease and diametes ,though normal lipids ,which can down-regulate main adverse cardiac events significantly . Key words: Statin; coronary heart disease ; diametes ; LDL-C ; hs-CRP;