Abstract
SUMMARY The split hand has been increasingly recognized as a clinical feature of amyotrophic lateral sclerosis (ALS), heralded by preferential wasting of the thenar group of muscles and the first dorsal interosseous. Although the mechanisms underlying the development of the split hand in ALS remain to be fully elucidated, a cortical basis has been suggested, thereby supporting the notion of upper motor neuron primacy in ALS pathophysiology. In addition, quantifying the split-hand phenomena through the recent development of a novel split-hand index, appears to robustly differentiate ALS from mimic disorders. Taken together, the split-hand index appears to be a useful neurophysiological parameter that has the potential to aid the diagnostic pathway in ALS. The current review discusses the pathophysiological, diagnostic and prognostic utility of the split-hand index in ALS.
Published Version
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