Abstract
Abstract An apparent compressive Young's modulus of elasticity of cylindrical tablets, produced from binary powder mixtures compressed at two tableting rates, was compared with the tensile strength isotropy expressed as the ratio of axial to radial tensile strength. The binary powder mixtures comprised materials which differ in yield pressure and in the extent of elastic deformation, plastic flow and fragmentation during their consolidation. A log-linear correlation was found between the apparent Young's modulus of elasticity of the tablets and the tensile strength isotropy, indicating that they were similarly related to the composition of the tablets. However, some differences in the effect of compression rate were evident. Thus, apparent Young's modulus varied with compression rate, depending on the principal consolidation mechanism of the component materials. In contrast, the tensile strength isotropy was virtually unaffected by an increase in the compression rate except for mixtures of paracetamol with Avicel which showed a slight decrease in isotropy. The tensile strength isotropy — a measure of the interparticle bonding isotropy - of the tablets could be improved by increasing the apparent Young's modulus, through the incorporation of a component, the particles of which undergo fragmentation or possess a high yield pressure.
Published Version
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