Abstract
Apoptosis is a process of programmed cell death that is critical for removal of unnecessary, injured, or contaminated cells, and is linked with various biological processes, which includes cell growth, isolation, and propagation. Lack of apoptosis may guide to cancer and autoimmune diseases, while too much cell death may increase ischemic conditions and promote neurodegeneration. The first mammalian gene that was responsible for cell death to be acknowledged was B-cell leukemia/lymphoma 2 (Bcl2), which was cloned from hematopoietic cell lines obtained from a translocation hot spot in follicular lymphoma. The discovery of Bcl-2 led to the discovery of many other key cell death regulators, such as Bcl-2 like 1 (Bclx), Bcl-2 linked protein x (BAX). With this background the objective of this study was to determination of protein structure of BAX of Chinese tree shrew (Tupaia belangeri chinensis) with the assistance of various bioinformatical research methods. A structural model of the BAX protein was generated and further analysis was carried out to infer molecular characteristics.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call