Abstract
Abstract We evaluated the inhibitory effect of 3,7-dinitrodibenzobromonium salts (cBr) on the proliferation of human chronic myelogenous leukemia K562 cell by trypan blue exclusion test and MTT colorimetric assay. The degree of DNA damage in K562 cells treated with cBr, was detected by isotopic tracer method (3H-TdR). The morphological changes of these K562 cells were examined by fluorescence and electron microscopy. Biochemical characteristics of K562 cells were detected by flow cytometry and 3H-thymidine incorporation assay. Findings indicated that cBr could significantly inhibit cell proliferation and result in DNA damage of K562 cells. cBr is a new type of immunostimulant and can induce cell apoptosis.
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