Abstract
Conclusion The reduced expression of these apoptosis factors in CRSwNP could be related to higher proliferation and perpetuation of inflammatory cells hindering the control of the disease. A better understanding of the possible influence of apoptosis factors on CRSwNP could be a rationale for future therapies. Author details School of Medicine of Ribeirao Preto University of Sao Paulo, Ribeirao Preto, Brazil. School of Medicine of Ribeirao Preto University of Sao Paulo, ENT Division, Ribeirao Preto, Brazil. School of Medicine of Ribeirao Preto University of Sao Paulo, Biochemistry Department, Ribeirao Preto, Brazil.
Highlights
The inflammatory process in chronic rhinosinusitis with nasal polyps (CRSwNP) has been extensively studied
The molecular assessment of mechanisms involved in apoptosis might shed light on the pathogenesis of CRSwNP
We observed significantly lower expression of p53 and caspases 3 and 9 genes in patients with CRSwNP compared to the controls, while caspase 7 expression was expressed in both groups
Summary
The inflammatory process in chronic rhinosinusitis with nasal polyps (CRSwNP) has been extensively studied. Apoptosis factors caspases and p53 and their impact in chronic rhinosinusitis with nasal polyposis Fabiana Valera1*, Daniel S Küpper2, Rafael Malinsky2, Cristiane Milanezi3, João S Silva3, Edwin Tamashiro2, Wilma T Anselmo-Lima2
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