Abstract
Apoptosis, or programmed cell death, is a central mechanism controlling cell number and the deletion of unwanted cells. Recent efforts have lead to the identification of the machinery involved in the control and execution of the apoptotic program Alteration of the normal apoptotic program has been identified as the possible cause of a number of human diseases, including neoplasia. In this review the means by which disruption of the normal apoptotic machinery may lead or contribute to tumor generation and progression will be discussed.
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