Abstract
The role of APOE4 in Alzheimers disease progression is an area of ongoing research. The core objective of this paper is to investigate the intricate interplay between APOE4, HSV-1, A, and AD progression. Methodology involves assessing A Levels, Spatial Recognition Memory, and Exploratory Behavior in HSV-1-infected Fx5AD Mice with APOE4, alongside monitoring specific biomarkers to confirm HSV-1 activation status. Our expected experimental outcomes suggest that APOE4 accelerates latent HSV-1 activation, leading to heightened A aggregation. Thus, we hypothesize that APOE4 may expedite latent HSV-1 activation, thereby facilitating A accumulation and AD advancement. The investigation of relationship between APOE4, HSV-1, A, and AD progression could give valuable insights into further experiments and treatments of AD.
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