Abstract
BackgroundAloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido. Therefore this study evaluates the aphrodisiac potential and acute toxicological effect of A. barbadensis (AB) root in male Wistar rats.MethodsAphrodisiac potential was determined following the oral administration of graded doses (100, 200 and 400 mg/kg) of ethanol extract of A. barbadensis root. Sildenafil citrate (Viagra) and distilled water served as positive and negative controls respectively. Sexual behavioural parameters (mounting and intromission frequencies, mounting, intromission and ejaculatory latencies) were observed. Serum testosterone and cholesterol concentrations were also progressively monitored on days 1, 7 and 14. The acute toxicological evaluation of the plant were based on any onset behavioural changes and mortality respectively.ResultsThe findings from the sexual behavioural study indicated that the ethanol extract of A. barbadensis significantly increased mounting frequency and intromission frequency but significantly decreased mount and intromission latencies in a dose dependent manner particularly on day 1 and 14. The ethanol extract also prolonged ejaculatory latency. The testosterone and cholesterol concentrations were also increased as the dose increased particularly on day 1 and 7. The lowest dose of 100 mg/kg showed the best aphrodisiac effect. The toxicity studies showed that there were no acute behavioural changes with zero mortality.ConclusionThe increased blood testosterone and cholesterol concentrations by the ethanol extract of A. barbadensis can probably be said to be the possible mechanisms of action for its aphrodisiac property. The plant may also be used to treat hypotestosteronemia following its ability to increase testosterone. These findings therefore give backing to the acclaimed local use of A. barbadensis root as an aphrodisiac in males.
Highlights
Aloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido
80% of the populations of the world still rely on local medicines and traditional treatments mainly from plant extracts [1, 2]
Preparation of extract The fresh roots of Aloe barbadensis were detached from the whole uprooted plant, rinsed in water and spread on laboratory tables where they were dried under room temperature
Summary
Aloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido. 80% of the populations of the world still rely on local medicines and traditional treatments mainly from plant extracts [1, 2]. It has been acclaimed that aphrodisiacs with a healthy lifestyle can achieve a better sexual life [5]. The sex is the most cherished, indispensable and an integral part of every individual and can be a cradle of pleasure and satisfaction. There has been erroneous information, unawareness, fear and pessimistic outlook as far as sex is concerned. Myths and misconceptions are widespread and are passed on from one generation to another.
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