Abstract
BackgroundTreatment for recurrent glioblastoma is poor, and there is a need for better therapies. Here we retrospectively assessed the efficacy and toxicity of temozolomide plus apatinib, an oral small-molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 in recurrent glioblastoma.Materials and MethodsA retrospective analysis of patients with recurrent glioblastoma who underwent apatinib plus temozolomide treatment was performed. Apatinib was given at 500 mg once daily. Temozolomide was administered at 200 mg/m2/d on days 1–5 or 50 mg/m2/d continuous daily according to whether they had experienced temozolomide maintenance treatment before. The main clinical data collected included tumor characteristics, status of MGMT promoter, and IDH mutation, number of relapse, response, survival, adverse reactions, and salvage therapies.ResultsFrom April 2016 to August 2019, thirty-one patients were identified. The objective response rate was 26.3%, and the disease control rate was 84.2%. The progression-free survival (PFS) at 6 months and overall survival (OS) at 12 months were 44.6 and 30.2%. The median PFS and OS were 4.9 and 8.2 months, respectively. Two patients achieved long PFS of 30.9 and 38.7+ months. The median survival time after progression of the patients with or without salvage bevacizumab was 5.1 versus 1.2 months. The most common grade 3 or 4 toxicities were hypertension (5.8%), decreased appetite (5.8%), and thrombocytopenia (4.3%), most of which were resolved after symptomatic treatment or dose reduction.ConclusionApatinib plus temozolomide is an effective salvage regimen with manageable toxicities for recurrent glioblastoma and could not reduce the sensitivity to bevacizumab.
Highlights
Glioblastoma is the most common and aggressive group of primary central nervous system tumors [1]
The most common grade 3 or 4 toxicities were hypertension (5.8%), decreased appetite (5.8%), and thrombocytopenia (4.3%), most of which were resolved after symptomatic treatment or dose reduction
We investigated the efficacy and safety of apatinib in combination with temozolomide in patients with recurrent glioblastoma
Summary
Glioblastoma is the most common and aggressive group of primary central nervous system tumors [1]. In 2005, Stupp and colleagues established a standard treatment for newly diagnosed glioblastoma consisting of concomitant chemoradiotherapy with temozolomide and maintenance treatment with temozolomide for 6 to 12 months. Even with current standard treatment, the median overall survival (OS) and progression-free survival (PFS) are only 14.6 and 6.9 months respectively for glioblastoma [2]. No standard of care has been established for patients with recurrent glioblastoma. Antiangiogenesis is a promising therapeutic strategy and vascular endothelial growth factor (VEGF) signaling is one of the bestcharacterized key therapeutic targets. Treatment for recurrent glioblastoma is poor, and there is a need for better therapies. We retrospectively assessed the efficacy and toxicity of temozolomide plus apatinib, an oral small-molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 in recurrent glioblastoma
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