Abstract
The effects of 3-hydroxypyridine and succinic acid derivatives (emoxypine, Reamberin, and Mexidol) on affective disorders in alloxan diabetes in rats were studied. The efficacies of emoxypine, Reamberin, and Mexidol were compared with that of α-lipoic acid (α-LA), which is regarded as the standard substance for the treatment of diabetic neuropathies. Courses of seven daily doses of emoxypine, Reamberin, and Mexidol, at doses equivalent to the therapeutic ranges for humans, were found to correct anxious-depressive disorders in rats with alloxan diabetes and were as effective as α-LA in terms of anxiolytic and antidepressant actions. Emoxypine and Mexidol differed from Reamberin and α-LA in that along with normalizing affective status, they decreased the extent of hyperglycemia. Emoxypine was more effective than Mexidol in terms of the tranquilizing action (at maximal doses), but was less effective in terms of the antidepressant effect (at minimal doses).
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