Abstract
The effect of original antioxidants - the derivatives of 3-hydroxypyridine and succinic acid (emoxypin, reamberin, and mexidol) made in Russia on metabolic disturbances, conditioned training, and motivated behavior was studied in rats with alloxan diabetes. Seven-day use of the test drugs was ascertained to normalize ill animals'behavior in the open field and to substantially upgrade the quality of the formed conditioned reflex of active avoidance. The derivatives of 3-hydroxypyridine and succinic acid are as effective as a-lipoic acid for experimental therapy of behavioral disorders and for conditioned training in alloxan diabetes. The psychotropic effects of the test antioxidants do not depend on their action on the blood levels of lipid peroxides in ill rats. Only emoxypin and mexidol have a concomitant modulating effect on the study manifestations of cerebral dysfunction, hyperglycemia, and dysllpldemia. Mexidol shows the best combination of positive metabolic and psychotropic effects in experimental diabetes mellitus.
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