Abstract
Background: Chronic illness is associated with vulnerability for anxiety disorders. Anxiety can negatively affect patient-reported outcomes. Aims: We hypothesized that anxiety prevalence will vary in a population tested for alpha-1 antitrypsin deficiency (AATD) based on age, gender, smoking status, and quality of life. We sought to determine if AAT genotype was independently related to anxiety. Methods: The Alpha Coded Testing (ACT) study offers confidential testing for AATD in individuals with diagnosed COPD and in AATD families. Psychosocial surveys, demographics, income and smoking status were collected. Multivariable analysis analyzed anxiety correlations as defined by Beck Anxiety Inventory (BAI) >22. A p-value Results: 1452 subjects had AATD genotype testing finding MM genotype in 50%, MZ in 36%, MS in 6%, ZZ in 4%, SZ in 2.5%. 1.5% had Znull, Mnull, or SS genotypes. Among AATD individuals or carriers, 9.2% had high BAI scores. In univariate analysis, anxiety was more prevalent in females (64% of study population) (OR=2.15; p Conclusions: Anxiety is common in those tested for AATD. Smoking status and income influence the prevalence of anxiety among populations tested for AATD. AAT genotypes and gender did not correlate with BAI scores in multivariate analyses. Strong correlation of high anxiety and SF12 scores was driven by MCS component.
Published Version
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