Abstract
White spot disease in penaeid shrimp is caused by white spot syndrome virus and causing serious threat to shrimp farming industry. The present study was carried out to determine the antiviral activity of Turbinaria ornata against WSSV in freshwater carbs Paratelphusa hydrodromous. The crabs were injected with acetone extract of T. ornata along with WSSV and the experimental groups were observed for more than 60 days post-infection. The efficacy of the T. ornata acetone extract was confirmed by bioassay, histopathology, and in silico analysis. GC–MS analysis of T. ornata acetone extract identified 16 compounds respectively. Docking studies recommended that pregnane-3,20-dione, 17,21-[(methylborylene)bis(oxy)]-, (5. beta)- had the highest binding energy of − 7.1 kcal/mol and could be used as a potent antiviral compound. The results of the present study confirmed that acetone extract of T. ornata has significant antiviral activity against WSSV and it can be used as a possible prophylactic in shrimp culture for prevention of WSSV infection.
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