Abstract
p-Hydroxyacetophenone (PHAP) isolated from Artemisia morrisonensis was found to have potential anti-HBV effects in HepG2 2.2.15 cells. The 2.4-kb preS RNA of viral surface gene increased significantly relative to the 2.1-kb S RNA with PHAP. Promoter activity analysis demonstrated that PHAP had a potent effect on augmenting the viral preS promoter activity. Interestingly, PHAP specifically reduced ER stress related GRP78 RNA/protein levels, but not those of GRP94 in treated Huh7 cells while PHAP also led to the significant intracellular accumulation of virus. In conclusion, this study suggests that the mechanism of HBV inhibition by PHAP might involve the regulation of viral surface gene expression and block virion secretion by interference with the ER stress signaling pathway.
Published Version
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