Abstract
The Sri Lankan Journal of Infectious Diseases (SLJID) is an open access, peer-reviewed, biannual journal published by the Sri Lankan Society for Microbiology (SSM). The Journal considers articles from all professional disciplines involved in the field of infectious diseases. The Journal has been in publication since 2011, is included in the DOAJ since 2018 and is a member of COPE since 2021. The SLJID practices a double-blind peer review policy. From 2022, the SLJID publishes accepted manuscripts online immediately after copy-editing, enabling rapid dissemination of scientific knowledge. The published articles are subsequently compiled into two issues in April and October. The SLJID does not charge any article processing or publication fee.
Highlights
Dengue is a major public health problem in tropical countries including Sri Lanka
The objective of this research was to determine the antiviral activity of C. papaya leaf extracts against dengue virus-1 (DENV1)
1/32- 1/256 dilutions were selected for treating the experimental DENV-1 infection. qRT-PCR showed DENV RNA in all 4 standards controls (SD1-107, SD2-106, SD3-105, SD4-104 DENV copies/ mL), positive control (5x107 DENV copies/ mL) and DENV-1 infected untreated control (3x104 copies/ mL). qRT-PCR did not show DENV RNA in negative control and four DENV-1 treated samples with 4 different concentrations of C. papaya leaf extracts
Summary
Dengue is a major public health problem in tropical countries including Sri Lanka. There are no specific antiviral drugs or an effective vaccine available against dengue as yet. Plant derived compounds are an important option for development of new drugs. Carica papaya of the family Caricaceae is a traditionally used medicinal plant to treat dengue. The objective of this research was to determine the antiviral activity of C. papaya leaf extracts against dengue virus-1 (DENV1). As a first step of exploring the antiviral activity, the cytopathic effects of the C. papaya leaf extract was done to select a minimum toxic concentration against the experimental DENV-1 infection in C6/36 cells
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