Abstract
The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 - 3000mg/kg) inhibited ethanol-induced, indomethacin - induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.
Highlights
From time immemorial plants have served as food and medicine to man
Vegetables and leaves of some trees domesticated or wild are used by the Ibibios of Niger Delta region of southern Nigeria in the preparation of their soup daily
The leaves are consumed as vegetable in southern Nigeria
Summary
Vegetables and leaves of some trees domesticated or wild are used by the Ibibios of Niger Delta region of southern Nigeria in the preparation of their soup daily. Some of these edible plants are medicinal and are used in the therapy of some diseases, majority of which have been reported to contain vital chemical compounds of medicinal importance. Lasianthera africana has been reported to be bacteriostatic (Itah, 1997), fungicidal (Itah, 1996) antidiabetic (Ekanem, 2006) and antiplasmodial (Okokon et al.,2007). The aim of the present study was to evaluate the antiulcer potential of the ethanolic extract of the dark green variety on some experimentally induced –ulcer models in rodents
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