Abstract
The present study was carried out to investigate antiulcer activity of methanolic bark extract of Premna serratifolia against aspirin induced gastric ulcer models of male wistar rats. In aspirin induced pylorus ligation model, various parameters were s tudied viz. volume and pH of gastric juice, total acidity, free acidity, ulcer score, ulcer index and percentage protection was determined. Ulcer score, ulcer index and percentage inhibition of ulceration was determined for ulcer model . Ranitidine (50 mg/kg p.o.) was used as the standard drug. Pretreatment with the extracts (200 & 400 mg/kg p.o.) showed significant protection against ulcer model . In aspirin induced pylorus liga ted model, the methanolic bark extract showed significant decrease in the volume of gastric juice, free and total acidity, ulcer score, ulcer index and increase in pH of gastric juice as compared to the toxicant control group. In conclusion, Premna serratifolia possess significant anti - ulcer and cytoprotective effect.
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