Abstract
In the Indian traditional system of medicine Operculina turpethum is commonly used to treat various ailments including peptic ulcer, inflammation, and pain. Ulcer preventive and ulcer protective activities of HAOP and MOP stem bark extracts of Operculina turpethum (100 mg/kg, b.w., orally) were evaluated employing aspirin + pylorus ligation (APL) model in experimental rats. The results suggested that both extracts (HAOP and MOP) possess enhanced ulcer preventive and protective activities when compared with the standard drug ranitidine. HAOP showed more pronounced effect when compared to MOP. Further the result of the histopathological and biochemical studies also confirms potent ulcer preventive and protective nature of a extracts in a similar manner.
Highlights
Peptic ulcer is one of the common disorders of gastrointestinal tract, which occur due to an imbalance between the offensive and defensive factors [1]
Plant Material. e dry stem of Operculina turpethum was purchased from the Indian Medical Practitioners Cooperative Society (IMCOPS) Chennai, Tamil Nadu, India which was authenticated by Dr S
Treatment with MOP and HAOP showed signi cant protection against ulcers in pretreatment (76.53% and 81.32%) and posttreatment (54.21% and 60.13%) at a dose of 100 mg/kg (PP P 0.001) when compared with the control animals, respectively. e standard drug, ranitidine, showed signi cant protective effects against ulcers (65.14%) at a dose of 50 mg/kg when compared with the control groups (PP P PPPPP) in both treatments
Summary
Peptic ulcer is one of the common disorders of gastrointestinal tract, which occur due to an imbalance between the offensive (gastric acid secretion) and defensive (gastric mucosal integrity) factors [1]. Stress, smoking, nutritional de ciencies, and fre uent intake of nonsteroidal-antiin ammatory drugs (NSAIDs) develop the peptic ulcer prevalence in the world [2]. Ese effects are the rationale for the development of new antiulcer drugs. A wide range of drug is currently available for treatment of gastric ulcer which includes proton pump inhibitors, H2blockers, antiacids, and anticholinergics. E most common adverse effects of these drugs are hypergastrinemia, hypersensitivity, gynecomastia, impotence, arrhythmia, and blood dyscrasias such as thrombocytopenia and enteric infections (Clostridium difficile) [3]. For this reason, the hunt is still on to discover a natural medicine having antiulcerogenic properties. A number of medicinal plants have been used for thousands of years in the traditional system of medicine (Ayurveda) to treat various diseases like peptic ulcer, cancer, diabetes, arthritis, hepatitis, acute and chronic in ammations, neurodegenerative diseases, and so forth [4]
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