Abstract
<br /><table class="data" width="100%"><tbody><tr valign="top"><td class="value"><p>In the present study, anti-ulcerative effects of extract of Brassica nigra L. leaves were investigated in pylorus ligation and aspirin-induced gastric ulcer models in rats. In present study antiulcer effect of ethanolic extract of Brassica nigra leaves is well understood by total acidity, free acidity, and ulcer index of different groups of animals in both the model viz. Pylorus ligation model &amp; Aspirin induced gastric ulcer in experimental rats when compared the test group with control and standard group. The percentage of ulcer inhibition was observed in pylorus ligated model was as follows: standard, BNLE 100mg/kg, BNLE 200mg/kg and BNLE 300mg/kg 55.76%, 30.96%, 49.54% and 51.35% respectively. The mechanism of gastric ulcer healing is not well understood and further study is needed to evaluate the specific phytoconstituents responsible for the gastric ulcer healing but on the basis of present study it can be concluded that this gastric healing potential may be due to the pharmacological effect played by the different phytoconstituents present in the ethanolic extract of Brassica nigra leaves for prevention of gastric mucosa or by the antioxidant potential of the leaves which is evaluated during the DPPH free radical scavenging activity.</p></td></tr></tbody></table>
Highlights
IntroductionPeptic ulcer is one of the major gastro-intestinal disorders, which occur due to an imbalance between the offensive (gastric acid secretion) and defensive (gastric mucosal integrity) factors [1]
Peptic ulcer is one of the major gastro-intestinal disorders, which occur due to an imbalance between the offensive and defensive factors [1]
The extract contains carbohydrates, glycosides, alkaloids, flavonoids, etc.In the present study, anti-ulcerative effects of extract of Brassica nigra L. leaves were investigated in pylorus ligation and aspirin-induced gastric ulcer models in rats
Summary
Peptic ulcer is one of the major gastro-intestinal disorders, which occur due to an imbalance between the offensive (gastric acid secretion) and defensive (gastric mucosal integrity) factors [1]. Reduction of gastric acid production as well as reinforcement of gastricmucosal production has been the major approaches for therapy of peptic ulcer disease. More and more drugs, both herbal and synthetic are coming up offering newer and better options for treatment of peptic ulcer. There are evidences for the participation of reactive oxygen species in the etiology and pathophysiology of human disease, such as neurodegenerative disorders, inflammation, viral infections, autoimmune gastrointestinal inflammation and gastric ulcer [3]. Drugs with multiple mechanism of protective action, including antioxidant activity, may be highly effective in minimizing tissue injury in human diseases.It has been demonstrated that many drugs and formulations possess potent antioxidant action and are effective in healing experimentally induced gastric ulcers [4,5,6]
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