Abstract
As a continuation of our chemical and biological studies on potential antitumor promoters (chemopreventive agents), we carried out primary screening of many kinds of natural products using their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12–0-tetradecanoylphorbol-13-acetate (TPA). The root of Panax notoginseng is well known as a traditional Chinese medicine having strong hemostatic and antiinflammatory activities. The extract of this plant and a major saponin of the crude drug, ginsenoside Rg, exhibited remarkable inhibitory effects on EBV-EA activation. Further, ginsenoside Rg1 also showed such inhibitory effects on the two-stage mouse skin carcinogenesis test, and the methanol (MeOH) extract of P. notoginseng exhibited similarly significant inhibitory effects on two-stage mouse skin [with 7,12-dimethylbenz[a]anthracene (DMBA) as initiator and TPA as promoter], pulmonary [with 4-nitroquinoline-N-oxide (4NQ0) as initiator and glycerol as promoter], and hepatic with N-nitrosodiethylamine (DEN) as initiator and phenobarbital as promoter] carcinogenesis tests by oral administration.
Published Version
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