Abstract
Alangiumines A–C (1–3), three novel additive pyridine alkaloids representing the unprecedented santanolide-anabasine, benzcyclohexanone-anabasine, and cyclopentenone-anabasine skeletons, were isolated from Alangium chinense. Their structures with absolute configurations were elucidated by spectroscopic techniques and electronic circular dichroism (ECD). Moreover, compound 1 exhibited selective antitumor in vitro activity against glioma stem cells (GSCs). This finding might provide new type of lead for the selective killing of human glioma stem cells.
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