Abstract
Methanol extract ofStellera chamaejasme L was assessed for antitumor activity by an antitumor active bioassay against murine leukemia P388in vivo. The bioassay-directcd separation of the extract furnished seven diterpene compounds (stellerarin, stelleramacrin, gnidimacrin, pimelea factor P2, subtoxin, huratoxin, simplexin ) and two biflavanone compounds (neochemae-jasmin A and B). Among them, gnidimacrin, stellerarin and stelleramacrin (a novel compound) were found to have high antitumor and cytotoxic activities against P388, L1210 and K562in vivo andin vitro. The results suggested that the diterpene compounds were the potent antitumor principlesof Stellera chamaejasme L.
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