Abstract
Levans were isolated from the cultures of Gluconoacetobacter xylinus (G-levan; M w=40,000), Microbacterium laevaniformans (M; M w=710,000), Rahnella aquatilis (R; M w=380,000), and Zymomonas mobilis (Z; M w=570,000). The levans were composed mainly of fructose residues when analyzed by TLC and HPLC, and their main backbones were β-(2,6)-linkages with β-(2,1)-branches by GC-MS and NMR. In the in vitro antitumor activity test of the levans against eight different tumor cell lines, relatively stronger activity was observed from the SNU-1 and HepG2. The M- (52.54–62.05%) and R-levan (52.15–58.58%) showed the significantly high activity against SNU-1, while M-levan showed the highest (49.93–61.82%) activity against HepG2. During the in vivo analysis of inhibitory activity of the levans against Sarcoma-180 growth, M-, R- and Z-levans showed strong antitumor activity (average 66%) but G-levan (42%) had significantly lower activity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Biological Macromolecules
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
