Abstract
In this study, a novel photosensitizer meso-tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) was reported. It displays a characteristic long wavelength absorption peak at 656 nm and it shows a singlet oxygen quantum yield of 0.48. After light irradiation with 650 nm laser, it can kill Eca-109 and SMMC-7721 cells in vitro (25 mW/cm2, 1.2 to 3.6 J/cm2) and destroy Eca-109 tumor in nude mice (50 mW/cm2, 90 J/cm2). It has the perspective to be developed as a new anti-tumor drug in photodynamic therapy (PDT) photodiagnosis, and deserves further investigation.
Highlights
Photodynamic therapy (PDT) is emerging as a promising method for the treatment of a variety of oncological, dermatological, cardiovascular and ophthalmic diseases.[1,2,3,4,5,6] PDT destroys target cells in the presence of oxygen when light irradiates a photosensitizer, generating highly reactive singlet oxygen and/or other reactive oxygen species (ROS) such as superoxide ion and hydroxyl radicals
Our results show the e±ciency of tetra (3-pyrrolidinomethyl-4-methoxyphenyl) chlorin (TPMC) for suitable PDT applications
TPMC can be excited at 420 nm, and its emission was monitored at wavelengths 656 nm
Summary
Photodynamic therapy (PDT) is emerging as a promising method for the treatment of a variety of oncological, dermatological, cardiovascular and ophthalmic diseases.[1,2,3,4,5,6] PDT destroys target cells in the presence of oxygen when light irradiates a photosensitizer, generating highly reactive singlet oxygen and/or other reactive oxygen species (ROS) such as superoxide ion and hydroxyl radicals. ROS attack biological targets, causing destruction through direct cellular damage, vascular shutdown and activation of an immune response against targeted cells.[7]. Photosensitizers in PDT play a critical role.[8,9] Selection of an appropriate photosensitizer is of paramount importance for PDT.[10] Factors that may in°uence the selection include conjugation compatibility and yield, quencher compatibility, photosensitizer hydrophobicity, excitation prole, singlet oxygen quantum yield, °uorescence quantum yields and photosensitizer dark toxicity.[3]
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