Abstract

Schachner, Franklin and Chaikoff1 found that the in vitro formation of diiodotyrosine and thyroxine by thyroid slices, using radioactive iodine, I131, as indicator is inhibited by cyanide, azide, sulphide and carbon monoxide (particularly in the dark). This indicates that the cytochrome oxidase system is involved in the synthesis of thyroxine by the thyroid gland. Franklin, Chaikoff and Lerner2, using the same technique, showed that thiourea and thiouracil in a concentration of 10–3 M inhibited the in vitro synthesis of diiodotyrosine and thyroxine.

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