Abstract
Objective: This study aimed to further investigate the antiplatelet and antithrombotic activities of Trigonella foenum-graceum (TFG) in vivo.Methods: Male mice were divided into two experimental groups (bleeding duration and survival rate). The study groups comprised vehicle controls(administered carboxymethyl cellulose [CMC]), negative controls (administered CMC), positive controls (administered aspirin), and experimentaltreatment groups (administered TFG extract at three doses). Bleeding duration was assessed by excising the tail vein. Survival rate was determinedby inducing thrombosis through intravenous collagen/epinephrine administration.Results: In mice treated with TFG extract for 7 days, bleeding duration was significantly increased compared with that in controls (p<0.05). Moreover,mice treated with TFG showed increased survival rates compared with negative controls.Conclusion: TFG extract showed antithrombotic activity in mice by significantly increasing bleeding duration and survival rate.
Highlights
Cardiovascular diseases, including thrombosis, stroke, ischemic heart disease, and coronary heart disease, are a leading cause of mortality
Thrombi formed in the circulatory system due to the disruption of homeostasis can cause vascular blockage, atherothrombotic diseases, and myocardial or cerebral necrosis, which can lead to death [2]
Trigonella foenum-graceum (TFG) or fenugreek is widely distributed in Indonesia and is consumed as a lactagogue by breastfeeding mothers
Summary
Cardiovascular diseases, including thrombosis, stroke, ischemic heart disease, and coronary heart disease, are a leading cause of mortality. Thrombi formed in the circulatory system due to the disruption of homeostasis can cause vascular blockage, atherothrombotic diseases, and myocardial or cerebral necrosis, which can lead to death [2]. Platelets are essential to maintain the vascular integrity and to stop bleeding through blood clot formation, but they have been implicated to play a role in the pathological progression of arterial vascular thrombosis through adhesion to injured vessels, aggregation to form plugs and acceleration of coagulation cascades [3]. Inhibiting platelet aggregation is a strategy for preventing cardiovascular diseases. A previous study has shown that fenugreek leaves possess antithrombotic activity [4]. Fenugreek seeds contain coumarin – a flavonoid with in vitro antithrombotic activity [5,6]
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