Abstract
Objective: This study aimed to investigate the antithrombotic activity of Tamarindus indica L. extract (TIE) in mouse models (in vivo).Methods: TIE was orally administered to mice at three different doses for 7 days. TIE-treated mice were used in two experiments of antithromboticactivity: An examination of bleeding time following tail cutting and an examination of survival rate after collagen-epinephrine-inducedthromboembolism. The TIE groups were observed after 7 days of treatment and compared to an aspirin-treated group and a control group.Results: Treatment with TIE led to a significant increase in bleeding time compared with that in the control group. TIE treatment also protected micefrom thromboembolic death, significantly increasing survival rates in a dose-dependent manner.Conclusion: TIE has the potential as an antithrombotic agent against platelet thromboembolism.
Highlights
Thrombosis, as one of the risk factors of cardiovascular disease, is the formation of a blood clot in an artery or a vein which starts with platelet aggregation [1,2]
Bleeding time Compared to the vehicle group, mice treated with single oral doses of T. indica L. extract (TIE) exhibited significantly increased bleeding times (p≤0.05)
The experimental group treated with the lowest TIE dose (14 mg/20 g mice) exhibited a 99% increase in bleeding time compared to the vehicle group
Summary
Thrombosis, as one of the risk factors of cardiovascular disease, is the formation of a blood clot in an artery or a vein which starts with platelet aggregation [1,2]. Tamarind (Tamarindus indica L.), a flowering plant within the family Fabaceae, is a potential antithrombotic agent due to its active compound dotriacontanoic acid [7]. This compound is one component of D-003, a natural compound comprising triacontanoic, dotriacontanoic, and tetradecanoic acid [8,9]. In vivo experiments with D-003 have demonstrated that this compound can reduce the formation of venous thrombus at a dose of 400 mg/kg in collagen-induced and epinephrine-induced mice [8]. The effects of T. indica L. extract (TIE) were tested in vivo on mice using bleeding time and survival rate as metrics of antithrombotic activity
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