Abstract
Twenty-three 7-alkoxycoumarins and related analogs were synthesized from 7-hydroxycoumarin by treatment with various alkyl/aryl/acyl halides and potassium carbonate in DMF. Their antifeedant and termiticidal activities against Coptotermes formosanus Shiraki were examined. Among the 23 compounds and control, 7-cyclohexyloxycoumarin (2k), exhibited the highest termiticidal activity in no-choice test, followed by 7-(4-nitrophenoxy)coumarin (2q), and 7-(2-butynyloxy)coumarin (2u) at 5 μmol/disc. On the other hand, all of 7-alkoxycoumarins showed antifeedant activity except 7-hexadecyloxycoumarin (2i) and 7-octadecyloxycoumarin (2j), while 7-ethoxycoumarin (2b) demonstrated the highest antifeedant activity. The results suggested that a presence of cyclohexyloxy and aryloxy groups at C-7 position of coumarin skeleton was found to be important for the termiticidal and antifeedant activities. Arylalkoxy groups having methoxy groups at benzene ring, alkenoxy, and alkynoxy groups led to analogs with good termiticidal activity, while the incorporation of alkoxy groups with longer alkyl chains tended to reduce both the termiticidal and antifeedant activities.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
