Abstract
This study explores the antiskin cancer effect of formulated agar (FA) from Laminaria digitata on dimethyl benzanthracene- (DMBA-) induced skin cancer mice. The agar was extracted and formulated (emulgel), and FA was biochemically characterized. The in vitro cytotoxicity of FA was tested using NTT 3T3 mice fibroblast cells. The mice were divided into 5 groups: group 1 served as control mice, group 2 mice were considered as DMBA-induced cancer control, group 3 mice were FA pretreated (low dose) + DMBA-induced mice, group 4 mice were FA pretreated (high dose) + DMBA-induced mice, and group 5 were positive control + DMBA-induced mice. The behaviour and biochemical markers of cancer were significantly decreased in group 2 (DMBA-induced) mice, which were brought to near normalcy by FA pretreated mice (groups 3 and 4). The levels of p53 and keratin were significantly elevated in group 2 mice and these levels were decreased in 3 and 4 mice as well. The histopathological examination of DMBA-induced mice was shown degenerated cervical patches in the skin, cirrhosis in liver, oedema in the renal tissue, and swollen and damage in cardiac tissue, which were reduced for the mice applied with FA. This confirms that FA pretreatment offered potential antiskin cancer property.
Highlights
Worldwide, 18.1 million new cases and 9.6 million deaths are due to skin cancer [1]
This is considered the maximum yield when compared to a previous report [22], which indicated that the agar yield from brown seaweeds could vary
A cost-effective hot water extraction method with comparable yield was successfully developed for agar extraction and its formulation to develop antiskin cancer property of formulated agar (FA) from brown seaweed (L. digitata) [23]
Summary
18.1 million new cases and 9.6 million deaths are due to skin cancer [1]. In India, 63% of death is due to noncommunicable diseases, and cancer is one of the dominating causes, accounting for 9%. These figures will nearly double by 2040; skin cancer is almost egregious malignancies among other common cancers though not ranked among the top ten common cancers [2]. There has been a continuous increase in the prevalence of skin cancers, especially that of cutaneous melanomas off the last few years. Most chemotherapeutics are dispensed methodically and are cytotoxic to normal cells; cancer case must undergo considerable morbidity.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
