Antipsychotic-like effect of Mitragyna speciosa in mice.

Abstract

Event Abstract Back to Event Antipsychotic-like effect of Mitragyna speciosa in mice. Kamini Vijeepallam1*, Murali Naidu2 and Vijayapandi Pandy1 1 University of Malaya, Department of Pharmacology, Faculty of Medicine , Malaysia 2 University of Malaya, Department of Anatomy, Faculty of Medicine , Malaysia Aim: The present study aimed to investigate the antipsychotic-like effect of methanolic extract of Mitragyna speciosa leaves (MMS) on apomorphine-induced climbing behaviour in mice. Method: Experiments were performed using swiss albino male mice (bodyweight 25-30g). In acute study, MMS at different doses 50, 75, 100, 125, 250 and 500 mg/kg, were administered orally one hour prior to apomorphine (5mg/kg, i.p) injection respectively. Immediately after injection of apomorphine, the mice were placed into cylindrical individual cages (12 cm in diameter and 17 cm in height) with the floor and wall consisting of vertical metal bars and recorded for climbing time and climbing behaviour. The climbing behaviour was scored as 0 = four paws on the floor, 2 = two paws on the wall of the cage, 4 = four paws on the wall of the cage. Data were analysed by using Graph Pad Prism version 5.0 Result: The results revealed that the acute oral treatment of MMS (50, 75, 100, 125, 250 and 500 mg/kg) showed an inverted bell-shaped dose-response in apomorphine-induced cage climbing behaviour in mice. Conclusion: In conclusion, this investigation provides first evidence that MMS exhibits anti-psychotic like behaviour in mice. Further studies are underway in our laboratory to unravel the exact mechanism of action of MMS for its antipsychotic-like activity. Keywords: Apomorphine, antipsychotic, in vivo, behaviour, natural product Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Poster Presentation Session Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Vijeepallam K, Naidu M and Pandy V (2016). Antipsychotic-like effect of Mitragyna speciosa in mice.. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00205 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 04 Aug 2016; Published Online: 11 Aug 2016. * Correspondence: Dr. Kamini Vijeepallam, University of Malaya, Department of Pharmacology, Faculty of Medicine, Kuala Lumpur, Wilayah Persekutuan, Malaysia, kamini88@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kamini Vijeepallam Murali Naidu Vijayapandi Pandy Google Kamini Vijeepallam Murali Naidu Vijayapandi Pandy Google Scholar Kamini Vijeepallam Murali Naidu Vijayapandi Pandy PubMed Kamini Vijeepallam Murali Naidu Vijayapandi Pandy Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.