Abstract
The antiproliferative properties of the synthetic steroid RU486 on the human lymphoma cell line Daudi are described. In suspension cultures, RU486 (10 microM) caused a time dose and cell density dependent reduction of cell proliferation. This effect was reversed within 48 h of withdrawal of RU486 from the growth medium. High concentrations of foetal calf serum can mask the inhibitory effect. In semi-solid cultures RU486 also impaired cell proliferation. Thus RU486 was able to suppress in this tumor cell line the expression of some properties frequently associated with the transformed status of the cells.
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