Abstract
Morus alba L. leaves has been used in fork medicine for the treatment of beriberi, edema, and diabetes and reported to have anti-obesity, anti-diabetic, anti-hypertension, liver protection, antiviral and antimicrobial activities. However, information on its anti-platelet and anti-thrombosis effects is limited. The current study was performed to examine the effects of M. alba leaves ethanol extract (MAE) in platelet aggregation and thrombosis. The anti-platelet activity of MAE was studied using rabbit platelets for in vitro determination of the extract effect on collagen-induced platelet aggregation, thromboxane B2 (TXB2) formation and serotonin secretion. The extract in vivo effects was also examined in arterio-venous shunt thrombus formation in rats. HPLC chromatographic analysis revealed that MAE contained rutin and isoquercitin. MAE significantly and dose dependently inhibited collagen-induced platelet aggregation with the 50 percent inhibitory concentration (IC50) of 0.42 mg/ml. MAE also attenuated serotonin secretion and thromboxane A2 formation. In addition, the extract in vivo activity showed that MAE at 400, 200 and 100 mg/kg significantly and dose-dependently attenuated thrombus formation in rat arterio-venous shunt model by 52.3% (p < 0.001), 28.3% (p < 0.01) and 19.1% (p < 0.05), respectively.
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