Abstract
Background: Human Immunodeficiency Virus (HIV) infection may alter antibody responses against periodontopathic bacteria, increasing the susceptibility for gingival and periodontal disorders in HIV-infected individuals. We describe the oral health of HIV-infected individuals receiving stable Antiretroviral Therapy (ART) and determine their association with serum anti-periodontopathic bacteria antibody level.
Highlights
Human Immunodeficiency Virus (HIV) infection is an important risk factor for gum and dental disorders
Nor were there differences between the viral load, CD4 count, or CD4/CD8 and the gingival and periodontal scores. This cross-sectional study of the oral health profile showed that gingivitis is common among HIV-infected individuals on stable Antiretroviral Therapy (ART)
Most of our study participants were on stable ART and virally suppressed, suggesting ART played an important role in reducing the development of severe periodontal disease in HIV-infected individuals
Summary
Human Immunodeficiency Virus (HIV) infection is an important risk factor for gum and dental disorders. Gingivitis and periodontitis may provide an avenue for oral pathogens to enter the bloodstream, resulting in systemic infection and inflammation [3,4]. The role of the periodontitis on inflammation is unclear but postulated to increase the risk of non-AIDS comorbidities such as cardiovascular diseases and insulin resistance. We hypothesized the risk of these comorbidities is higher in HIV-infected individuals, in particular with the interplay between systemic immune activation and periodontitis-related systemic infection. Human Immunodeficiency Virus (HIV) infection may alter antibody responses against periodontopathic bacteria, increasing the susceptibility for gingival and periodontal disorders in HIV-infected individuals. We describe the oral health of HIV-infected individuals receiving stable Antiretroviral Therapy (ART) and determine their association with serum anti-periodontopathic bacteria antibody level
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