Abstract
Objectives: Aluminum phosphide (AIP) is the commonly used pesticide in agriculture, which induces oxidative stress in almost all major body systems and organs. The aim of this study was to evaluate the efficacy of nanocurcumin and curcumin on serum oxidative stress level in subacute toxicity with AIP. Materials and Methods: In this study 36 male Wistar rats (220-250 g) were randomly divided into six groups. Control (C) receiving normal saline; group AIPreceiving AIP (2 mg/kg daily); group Cur receiving curcumin (100 mg/kg daily); group Nano-cur receiving nanocurcumin (100 mg/kg daily); group AIP+ Cur receiving AIP (2 mg/kg daily) and curcumin (100 mg/kg daily); and group AIP and Nano-cur receiving AIP (2 mg/kg daily) and nanocurcumin (100 mg/kg daily). Serum total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol groups (TTG), and catalase (CAT) activity were measured. Results: AIP administration led to a significant increase in LPO, and decreased the CAT activity, TAC, and TTG compared to the control group (P<0.05). Curcumin and nanocurcumin caused a significant decrease in the levels of LPO compared to the AIP-exposed groups (P<0.05). Moreover, in the nanocurcumin-treated groups, compared to a poisoned group, TAC and TTG increased significantly (P<0.01). There were no significant changes in CAT activity improvement. Conclusion: Nanocurcumin and curcumin improved the AIP-induced oxidative damage.
Highlights
Aluminum phosphide (AIP) is known as “rice pill” in Iran and is extensively used due to its protective effects on grain storage [1,2]
Lipid Peroxidation According to the results of the present study, serum lipid peroxidation (LPO) level increased significantly in AIP-exposed group compared to the control group (P < 0.01)
Treatment with curcumin (P < 0.05) and nanocurcumin (P < 0.01) led to an improvement in LPO compared to the poisoned group
Summary
Aluminum phosphide (AIP) is known as “rice pill” in Iran and is extensively used due to its protective effects on grain storage [1,2]. The main mechanism of AIP-induced toxicity is the disruption of the balance between the production and neutralization of active radicals, which is known as oxidative stress. Antioxidant defense mechanisms have been designed to neutralize or minimize the harmful effects of free radicals [8]. Antioxidants such as glutathione peroxidase (GPx), CAT, SOD, uric acid, bilirubin, and thiol group molecules are produced within the body [9]. Exogenous antioxidants, such as vitamin E or alpha-tocotrienols need to be supplied via diet [10]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
