Abstract
Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives
Highlights
Beta-Carotene and Retinol Efficacy Trial (CARET) evaluated the effect of oral intake of beta-carotene and retinol in 18,314 men and women at high risk for lung cancer, but it had to be discontinued due to increased incidence of lung cancer, cardiovascular disease, and mortality
The involvement of free radicals and oxidative stress in the molecular mechanisms related to ageing, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear
Some authors believe that even pro-oxidant agents or processes, which were earlier recommended to be avoided, may be important to maintain a healthy status, as low/mild exposure to free radicals would help cells to maintain an effective antioxidant defense system through physiological mechanisms, in a process that could be called “oxidative stress preconditioning.”
Summary
Beta-Carotene and Retinol Efficacy Trial (CARET) evaluated the effect of oral intake of beta-carotene and retinol in 18,314 men and women at high risk for lung cancer, but it had to be discontinued due to increased incidence of lung cancer, cardiovascular disease, and mortality. Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives
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