Abstract
Background: Accumulating reactive oxygen species (ROS) is involved in cellular signaling and function disturbances due to the oxidative stress, which contributes to several diseases. The consequences of ROS activity represent an im-portant mechanism on the pathogenesis of vascular diseases, such as hypertension. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Resveratrol, a polyphenolic compound primarily found in red wine, has many biological and pharmacological proper-ties. Considering the antioxidant properties of resveratrol, the present study was aimed to investigate the effects of the chronic treatment with resveratrol on cardiovascular system from renal hypertensive rats. Results: 2K-1C hypertension presented increased blood pressure, which was reduced at the end of the fifth week of resveratrol treatment. The cardiac hypertrophy index and the basal levels of ROS in rat aortic rings were also reduced by resveratrol treatment. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the car-diac growth and the vascular ROS generation in renal hypertension.
Highlights
Hypertension is a well-studied risk factor for several car diovascular diseases
The contraction evoked by phenylephrine in aorta from 2 kidneys (2K) Resv group (Emax: 99.25 ± 2.71%; pD2: 8.6 ± 0.27, n = 5) or 2 kidneys-1 clip (2K-1C) Resv group (Emax: 97.32 ± 2.39%; pD2: 7.5 ± 0.057, n = 5) was not different from that one evoked in aorta from 2K control group (Figure 3). 3.4
The results clearly demonstrated the benefits of resveratrol treatment over cardiovascular indexes that are related renovascular hypertensive condition
Summary
Hypertension is a well-studied risk factor for several car diovascular diseases. It has been established that hypetension is associated with cardiovascular damages such as endothelial dysfunction, microvascular impairments [1] and cardiovascular remodeling [2,3]. The pathological processes underlying hypertension have been extensively studied by applying some animal models [4], such as the 2-kidneys-1Clip (2K-1C) renovascular hypertension In this model, designed by Goldblatt and cols in 1934 [5], a partial stenosis in the left renal artery is caused by placing a silver clip on the arterial side close to the aorta. This stenosis elicits a sustained increase in blood pressure mainly due to the increased plasma renin activity and subsequent increased circulating angiotensin-II (Ang. II) [6]. Increased blood pressure observed in renal hypertension of the 2 kidneys-1 clip (2K-1C) model involves increased ROS levels in the cardiovascular system. Conclusions: The present findings clearly show the protective effects from resveratrol on the blood pressure, the cardiac growth and the vascular ROS generation in renal hypertension
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