ANTIOXIDANT PROPERTY OF ANTIHYPERTENSIVE DRUGS (CARVEDILOL, ENALAPRIL, AND AMLODIPINE) ON LIVER FUNCTION IN ANIMAL (RATS) MODELS

Abstract

<p>ABSTRACT<br />Objective: The antihypertensive drugs (beta-blockers - carvedilol, calcium channel blocker - amlodipine, and angiotensin-converting enzyme<br />inhibitor - enalapril) were investigated for its hepatoprotective effect by antioxidant property against carbon tetrachloride (CCl<br />)-induced acute liver<br />damage on albino rats. <br />Methods: In this study the liver was damaged by giving Carbon tetra chloride (CCl<br />4<br />)-1 ml/kg-p.o. After giving CCl<br /> (1 ml/kg), it significantly elevated<br />the serum levels of biochemical markers such as serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, alkaline<br />phosphatase, total bilirubin, protein, and depleted antioxidant enzymes glutathione. After treatment with carvedilol (10 mg/kg), enalapril (0.5 mg/kg),<br />and amlodipine (10 mg/kg) for 2 weeks, these drugs were significantly reduces the elevated levels of biochemical markers mentioned above.<br />Conclusion: These results suggest that these antihypertensive drugs may have the potential therapeutic value in the treatment of CCl<br />4<br />-induced<br />hepatic damage and some liver diseases. Hepatoprotective activity of these drugs may be attributed to the antioxidant principles in it.<br />Keywords: Antioxidant, Carvedilol, Enalapril, Amlodipine, Carbon tetrachloride, Hepatoprotective.<br />4</p><p>4</p>