Curative effect of Abhrak bhasma on liver and kidney functions of ccl4 induced toxicity in albino rat

Abstract

In Ayurveda, many drugs are mentioned to treat liver and kidney diseases. Abhrak bhasma is commonly used Ayurvedic medicine against many diseases including hepatitis. This study was planned to investigate the curative effect of abhrak bhasma in liver and kidney functions in CCl 4 induced hepatotoxicity. Various doses of abhrak bhasma (10, 20, 30 and 40 mg/ kg body wt) were given in curative experimental schedule in male albino rat. Administration of CCl 4 increased serum Aspartate Transaminase (AST), Alanine Transaminase (ALT) and Alkaline Phosphatase (ALP) activities reflected intoxication that produced cellular degeneration or destruction. With increasing doses of abhrak bhasma given to CCl 4 treated rats in 7 days hepatocure schedule normalized the elevated activities of AST, ALT and ALP. Similarly CCl 4 mediated increased contents of conjugated, unconjugated and total bilirubin level was reduced with increasing doses of abhrak bhasma suggesting dose dependent bilirubin clearance efficiency. Abhrak bhasma also mediated urea and creatinine clearance indicating renal curative potency. It was found that abhrak bhasma has more curative effects than SiO 2 doses. The present findings concluded that abhrak bhasma possess dose dependent curative effects against CCl 4 intoxicated liver and kidneys functions in albino rat.