Abstract
Plants are rich sources of a diverse range of chemicals, many of which have significant metabolic activity. One large group of secondary compounds are the phenolics, which act as inter alia potent reactive oxygen scavengers in cells, including fibroblasts. These common dermis residue cells play a crucial role in the production of extracellular matrix components, such as collagen, and maintaining the integrity of connective tissue. Chronic wounds or skin exposure to UV-irradiation disrupt fibroblast function by the generation of reactive oxygen species, which may damage cell components and modify various signaling pathways. The resulting imbalance may be reversed by the antioxidant activity of plant-derived phenolic compounds. This paper reviews the current state of knowledge on the impact of phenolics on fibroblast functionality under oxidative stress conditions. It examines a range of compounds in extracts from various species, as well as single specific plant-derived compounds. Phenolics are a good candidate for eliminating the causes of skin damage including wounds and aging and acting as skin care agents.
Highlights
Plants are a rich source of structurally diverse chemical compounds
The following data regarding the plant extracts with phenolic content was collected in a table: the name of the family, the scientific names of the species, parts of the plants used for extract preparation, types of extract, compounds identified in the extracts, fibroblast cell line and the mechanisms of action, as well as the reference to the paper
human dermal fibroblasts (HDFs) treatment activates collagen production, inhibition of matrix metalloproteinases (MMPs)-1 protein expression, and upregulation of tissue inhibitors of metalloproteinase (TIMPs)-1 secretion [104]. These findings show that phenolic compounds synergistically accelerate fibroblasts and are effective in the wound healing process
Summary
Plants are a rich source of structurally diverse chemical compounds. Nowadays, these chemical compounds are of great interest in several fields of science including pharmacy and cosmetology. In vitro studies indicate that these chemicals are able to modify several biomolecular pathways in cells [5] They have been found to mediate protection against oxidants via stimulation of nuclear factors (erythroid-derived 2), factor 2 (Nrf2) [14] and inhibition of mitogen-activated protein kinases (MAPKs); they suppress the expression of matrix metalloproteinases (MMPs), which are known to disrupt collagen and limit nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) signaling and pro-inflammatory agent release [15]. This paper reviews the properties of selected plant extracts from various species rich in phenolic compounds, as well as isolated phenolics, on fibroblast cells It examines the potential of phenolics as ROS scavengers and as important agents for mediating wound healing and anti-aging processes under oxidative stress conditions
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