Abstract
Purpose: To investigate the antioxidant, hypoglycemic and antidiabetic activities as well as the phenolic composition of Ziziphus spina-christi (ZSC)Methods: Eighty percent methanol extract (ZSC-1), as well as ethyl acetate (ZSC-2), n-butanol (ZSC-3) and aqueous (ZSC-4) fractions were administered orally to mice at doses of 250 and 500 mg/kg of body weight. The hypoglycemic and anti-diabetic activities of these fractions in the treated mice were evaluated after 7 and 15 days, using glibenclamide as a standard. Antioxidant activities in vitro were determined using stable free radical DPPH and ABTS radical scavenging techniques.Results: The strongest (p < 0.001) anti-diabetic activity (25.59 and 39.48 % after 7 and 15 days, respectively) was found following treatment with 500 mg/kg ZSC-3 fraction. Similarly, the highest (p > 0.001) hypoglycemic effect was achieved with 500 mg/kg ZSC-3 treatment (29.07 and 35.56 % after 7 and 15 days, respectively). ZSC-1 possessed the highest content of total flavonoids (36.2 mg/g) and total polyphenol (82.3 mg/g).Conclusion: Fraction ZSC-3 displayed potential hypoglycemic activity while ZSC-1, ZSC-2 and ZSC-3 possess remarkable DPPH scavenging ability equivalent to 89, 96 and 80.3 % of the activity of the standard drug respectively.Keywords: Ziziphus spina, Rhamnaceae, Hypoglycemic, Anti-diabetic, Flavonoids, Polyphenol
Highlights
Diabetes mellitus, a metabolic disorder, causes damage to the heart, blood vessels, nerves, kidney and eyes
We aimed to evaluate the composition of the flavonoid and polyphenolic compounds in addition to the antioxidant and the anti-diabetic activities of the extract and various fractions of Ziziphus spina-christi (ZSC)
The highest results 25.59 % (7 days) and 39.48 % (15 days) were found after the administration of 500 mg/kg body weight ZSC-3 compared with standard drug
Summary
A metabolic disorder, causes damage to the heart, blood vessels, nerves, kidney and eyes. Within the 25 years, diabetes is projected to be one of the major causes of death throughout the world. Medicinal plants are used to treat many diseases, every year, a large numbers of novel natural product are isolated with efficacy against various diseases. Medicinal plants are a potential source of therapeutic agents [2]. In this study plants we assessed the potential of Zizyphus spina-christi which belong to Genus Zizyphus and family Rhamnaceae. Ziziphus species are a group of small trees that grow in many regions of the world. They belong to but are native to subtropical and temperate regions
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