Abstract
This research is supported by Atatürk University Scientific Research Commission. Abstract This study, it was aimed to determine the antioxidant effect of bilberry extract in decreasing the oxidative stress caused by acute exhaustive exercises in rats' blood and liver tissues. 27 Spraque-Dawley type male rats were divided into four groups (control, exercise, bilberry and bilberry+exercise groups). Bilberry extract was administered using gavage once daily. Before blood and liver tissues were taken, the rats ran in a treadmill at a speed of 25 m/min (1.5 km / h) at a slope of 0 for about 1 hour or until exhaustion. Compared to the control group, serum GSH levels and GPx activities did not have a significant change in the bilberry, acute exercise and bilberry + acute exercise groups; while serum MDA levels decreased significantly. When compared to the control group, liver GPx activity significantly increased in the bilberry and bilberry+acute exercise groups. Again, it was determined that liver GSH level significantly increased in bilberry+acute exercise group.The results of this study demonstrate that bilberry extract may provide antioxidant protection against a potential oxidative damage as it causes an increase in hepatic GPx activity and GSH levels in rats exposed to acute exhaustive exercise. Keywords: Antioxidants, acute exhaustive exercise, bilberry, glutathione, glutathione peroxidase, malondialdehy DOI: 10.7176/JMPB/65-04 Publication date: April 30 th 2020
Highlights
While exercise has many beneficial effects on health[1], there are many findings that a certain amount of oxidative damage occurs in muscle, liver, blood, and other tissues during exercise, and reactive oxygen species (ROS) and free radical production increase especially in intense exercises[2,3,4].The most significant biological change that occurs during exercise is the increase in the rate of oxygen consumption.[5]
It was determined that liver GSH level significantly increased in bilberry+acute exercise group.The results of this study demonstrate that bilberry extract may provide antioxidant protection against a potential oxidative damage as it causes an increase in hepatic Glutathione Peroxidase (GPx) activity and GSH levels in rats exposed to acute exhaustive exercise
Serum MDA, GSH levels and GPx activities of B, E and B+E groups were compared with the C group, there was no significant difference in GSH levels and GPx activities, while serum MDA levels decreased in a significant rate
Summary
While exercise has many beneficial effects on health[1], there are many findings that a certain amount of oxidative damage occurs in muscle, liver, blood, and other tissues during exercise, and reactive oxygen species (ROS) and free radical production increase especially in intense exercises[2,3,4].The most significant biological change that occurs during exercise is the increase in the rate of oxygen consumption.[5]. While exercise has many beneficial effects on health[1], there are many findings that a certain amount of oxidative damage occurs in muscle, liver, blood, and other tissues during exercise, and reactive oxygen species (ROS) and free radical production increase especially in intense exercises[2,3,4]. Lipids can initiate oxidative stress, which causes different cellular damages affecting proteins and nucleic acids.[8,9,10] Antioxidant enzymes that are effective at the cellular level against ROS, which is produced during exercise, include SOD (superoxide dismutase), CAT (catalase), GPx (glutathione peroxidase) and GSH (Glutathione)[11]. Acute exercise leads to muscle tissue damage, lipid peroxidation in membranes and the formation of free radicals[4]. Regular and short-term submaximal exercises activate antioxidant systems more often while the damaging oxidant system becomes more active in intense and long exercises[6,13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
