Abstract
Some indicative factors of antioxidant capacity in erythrocytes from chronic copper poisoning in sheep, were evaluated. Levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, reduced glutathione (GSH) and response to oxidative shock have been determined in animals with high and normal copper status. High copper status might have limited the SOD activity and induced lowest levels of GSH. This was associated with an increase of TBA reactivity in lipid peroxidation induced by hydrogen peroxide. In addition, GSH-Px activity did not differ significantly from that of control sheep. Our results demonstrate a direct correlation between the level of serum copper and a decrease in the evaluated antioxidant mechanisms. It is reasonable to postulate that non-specifically bound copper could be involved in cellular injury.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
