Abstract
Some indicative factors of antioxidant capacity in erythrocytes from chronic copper poisoning in sheep, were evaluated. Levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, reduced glutathione (GSH) and response to oxidative shock have been determined in animals with high and normal copper status. High copper status might have limited the SOD activity and induced lowest levels of GSH. This was associated with an increase of TBA reactivity in lipid peroxidation induced by hydrogen peroxide. In addition, GSH-Px activity did not differ significantly from that of control sheep. Our results demonstrate a direct correlation between the level of serum copper and a decrease in the evaluated antioxidant mechanisms. It is reasonable to postulate that non-specifically bound copper could be involved in cellular injury.
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