Abstract
One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid.
Highlights
Interests in using natural products as starting materials for drug discovery has benefitted many therapeutic areas especially infectious diseases and oncology
In previous communications we have reported the screening of thirteen Artocarpus species for biological activity and one of the plants, Artocarpus obtusus, was chosen for further detailed phytochemical and biological evaluation [15]
The compounds were evaluated for the antimicrobial activity using disc diffusion method and tested against eight bacterial and three fungal strains with streptomycin sulfate, gentamicin sulfate and nystatin used as positive controls in the assay
Summary
Interests in using natural products as starting materials for drug discovery has benefitted many therapeutic areas especially infectious diseases and oncology. As well as other natural sources offer many important and active natural products which may differ in structure and biological properties. Many interesting biological activities were investigated and reported from previous phytochemical work on plant extracts and pure compounds isolated from Artocarpus species [5,6,7,9,13,14]. In. continuation of our work on bioactive compounds from local plants [18,19,20], in this report we wish to further highlight the results of biological activity of the three xanthones when tested for antioxidant, antimicrobial and tyrosinase inhibitory activities.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
