Abstract
Background: Development of biodegradable and biocompatible films based on protein polymer with strong antioxidant and antibacterial activities has gradually obtained extensive concern in the world. In this study, the improvement of gelatin film properties incorporated with Ferula assa-foetida essential oil (FAO) as a potential antioxidant/antibacterial wound dressing film was investigated. Materials and Methods: Gelatin films were prepared from gelatin solutions (10% w/v) containing different concentration of FAO. The effect of FAO addition on water solubility, water swelling, water vapor permeability, mechanical behavior, light barrier properties as well as antioxidant and antibacterial activities of the films were examined. Results: Water solubility, water swelling and water vapor permeability for pure gelatin films were 29 ± 1.6%, 396 ± 8%, 0.23 ± 0.018 g.mm/m2.h, respectively. Incorporation of FAO into gelatin films caused a significant decrease in swelling and increase in solubility and water vapor permeability. Tensile strength, elastic modulus and elongation at break for pure gelatin films were 4.2 ± 0.4 MPa, 5.8 ± 4.2 MPa, 128 ± 8 %, respectively. Incorporation of FAO into gelatin films caused a significant decrease in tensile strength and elastic modulus and increase in elongation at break of the films. Gelatin film showed UV-visible light absorbance ranging from 280 to 480 nm with maximum absorbance at 420 nm. Gelatin/FAO films also exhibited excellent antioxidant ad antimicrobial activities. Conclusions: Our results suggested that gelatin/FAO films could be used as active films due to their excellent antioxidant and antimicrobial features for different biomedical applications including wound-dressing materials.[GMJ.2015;4(2):103-14]
Highlights
IntroductionGelatin (a denatured collagen peptide with MW=100 Kilo Dalton) is a soluble protein obtained by partial acid/alkaline hydrolysis of insoluble native collagen
Gelatin is a soluble protein obtained by partial acid/alkaline hydrolysis of insoluble native collagen
Kavoosi and Rowshan have shown that foetida essential oil (FAO) possesses nitric oxide (NO) and malondialdehyde scavenging properties and could prevent nitrative stress and lipid peroxidation [23]. These results demonstrated that FAO synergistically increased antioxidant activity of gelatin and gelatin films incorporated with FAO could be a promising candidate for safe radical scavenger wound dressing material
Summary
Gelatin (a denatured collagen peptide with MW=100 Kilo Dalton) is a soluble protein obtained by partial acid/alkaline hydrolysis of insoluble native collagen. There is a growing interest in using plant extracts as natural sources of antioxidant/antibacterial compounds in the formulation of gelatin films [10] In this context, plant essential oils and their main components are gaining a wide interest in health industry for their potential as antioxidant and antimicrobial agents [11]. The aim of this work was to develop gelatin films incorporated with different concentrations of FAO in order to obtain improvements in water solubility, water swelling, water vapor permeability, tensile strength, elastic modulus, elongation at break, light barrier, antioxidant and antimicrobial properties of the film. The improvement of gelatin film properties incorporated with Ferula assa-foetida essential oil (FAO) as a potential antioxidant/antibacterial wound dressing film was investigated. Conclusions: Our results suggested that gelatin/FAO films could be used as active films due to their excellent antioxidant and antimicrobial features for different biomedical applications including wound-dressing materials.[GMJ.2015;4(2):103-14]
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